Description
Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people-s varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.
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## The Position ##
A healthier future. It-s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.
That-s what makes us Roche.
In Roche´s Pharma Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world-s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
This position is anchored into the Nucleic acid-based Medicine (NABM)-Genomic Medicine matrix organization. The position holder will be a member of the newly formed Applied Viral and Non-Viral Technologies (AVANT) team.
The AVANT team areas of focus encompasses rAAV supply, AAV & capsid engineering, DNA plasmid engineering and overall utilizing knowledge gained from AAV biology to improve AAV potency. Overall, our aim is to contribute to the field of AAV research and further improve gene therapy products.
## Role Mission ##
We are offering an outstanding opportunity for a senior associate to work within a multidisciplinary team of scientists dedicated to producing new rAAV to supply internal research projects. You will participate in, but not be limited to, the execution of established protocols for production of research grade rAAV vectors, as well as development of improved protocols that pertain to increasing rAAV titer, cell lysis, clarification, column chromatography, gradient centrifugation, vector characterization. Additionally, the individual will be involved in the engineering, screening of new rAAV with improved manufacturability and potency. Additionally, the individual will contribute to the implementation of documentation, scale up, troubleshooting and data analysis in order to support the supply of research-grade rAAV vectors.
## Your Impact ##
* Perform bench-scale expression, purification and characterization of rAAV according to established protocols to support AAV supply
* Conduct rAAV supplies, purification and process optimization experiments at multiple scales to support AAV supply and improve existing procedures
* Screen, test and characterize newly engineered AAVs, libraries to improve AAV manufacturability and potency
* Contribute to protocols, perform preliminary analyses and prepare internal reports to support scientific conclusions
* Participate in laboratory management: lab organization, ordering, equipment maintenance and qualification, etc.
* Thoroughly document performed experiments in our electronic laboratory documentation system and present findings in internal events.
## Your Profile ##
You are an enthusiastic associate with a background in biotechnology, biology, bioengineering, biochemistry or a relevant life science field. You bring interest and hands-on lab experience in AAV production, purification & characterization, molecular cloning strategies, NGS library preparation for AAV variant screening.
You thrive in a dynamic, inclusive environment, which gives you full accountability for your own contributions and development. You have a keen interest in continuously building a personal network. You are resourceful and flexible in problem solving and in working in a collaborative and inclusive manner. You have a sense for ensuring that everyone has the required information at all times. You have strong oral and written communication skills and are proficient in working with cross-functional and multidisciplinary teams.
Your Professional Training and Experience
Scientific studies (Master (FH), alternatively Master (Univ.) or Engineer / Bachelor) with professional experience or scientific vocational training with further training as a technician and three years of specific work experience.
IT-Skills (MS Office, lab software applications), good English skills
## Our commitment ##
Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.
We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
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## Who we are ##
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we-ve become one of the world-s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche\`s largest sites. Read more.
Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.
We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.
**Roche is an Equal Opportunity Employer.**