Descripción
In this diverse and impactful role, you will be at the forefront of driving Numab’s lead candidates
from research into development and clinical stages. As a key member of our team, you’ll be
responsible for developing robust liquid and lyophilized formulations of our multi-specific
antibody-based therapeutics.
Your Responsibilities:
- Lead developability profiling of our biologics to ensure their suitability for clinical development
- Design and execute formulation studies – with a focus on parenteral liquid formulations – using statistical approaches such as Design of Experiments (DoE)
- Analyze formulation stability using a range of analytical methods including SE-HPLC, CEX-HPLC, cGE and others
- Drive early-phase biophysical screening – enhancing throughput while minimizing material use, and exploring new analytical technologies
- Interpret and present scientific data to internal teams and external stakeholders, proposing clear next steps for project progression
- Collaborate cross-functionally with team members to accelerate development and ensure timely project delivery
- Support lab operations – including the organization, evaluation, and procurement of equipment and consumables
Ideal candidates will have:
- Completed MSc or PhD in biochemistry, biophysics or pharmaceutical sciences with industry experience in the field of biophysical assessment and/or development of liquid parenteral formulations of biologics
- Theoretical and practical expertise in evaluating protein biophysics and stability, such as colloidal, interfacial, and chemical stability to withing developability assessment and formulation development
- Experience in (high concentration) liquid formulation development of biologics and good understanding of relevant analytical methods to monitor stability, e.g. SE-HPLC, CEX-HPLC and cGE
- Professional experience in high throughput screens including the use of DoE
- Expertise in advanced data evaluation and analysis
- Initiative, problem solving skills, self-motivation and curiosity
- Highly accurate and team-oriented working style paired with a high sense of quality
- Excellent documentation, reporting and communication skills in English
What we offer:
- A diverse field of activities in a dynamic team with an inspiring, entrepreneurial atmosphere
- Flat hierarchies and short decision-making paths
- The opportunity to take responsibility, help shaping and implementing solutions
- Employment conditions in line with the market, superior pension plan, flexible working time model, and opportunities for further personal development
- Performance-based bonus and participation in the employee stock option plan
- Several fun team events throughout the year
- A workplace near the city of Zurich, overlooking the lake